Association among 25‐hydroxyvitamin D levels, hypertriglyceridemic‐waist phenotype, and cardiometabolic markers in individuals with type 2 diabetes mellitus from regions with high solar incidence.

Objective: To evaluate the relationship between vitamin D status and hypertriglyceridemic‐waist (HTW) phenotype and cardiometabolic markers in individuals with type 2 diabetes mellitus (T2DM) living in regions with high solar incidence (10° south). Methods: An observational, cross‐sectional study, with 122 individuals with T2DM, of both sexes, aged between 19 and 59 years, residing in Sergipe/Brazil. Measurements included serum 25‐hydroxyvitamin D (25[OH]D), glucose, insulin, total cholesterol, LDL‐c, HDL‐c, triacylglycerols, blood pressure, body mass index, %body fat, and waist circumference. Participants were classified by the presence or absence of the HTW phenotype, according to increased waist circumference and triacylglycerols concentrations. Logistic and linear regression models were applied to verify the association among the concentration of 25(OH)D, HTW phenotype, and lipid profile variables. Results: Triacylglycerols concentrations (p =.013) and %body fat (p =.011) were higher in women with serum 25(OH)D insufficient/deficient than in those with adequate 25(OH)D levels. Individuals with serum 25(OH)D insufficiency/deficiency were 2.595 times more likely to present the HTW phenotype than those with adequate 25(OH)D levels (p =.021). Additionally, a negative association was observed between the concentration of 25(OH)D and total cholesterol (Beta = −0.204, p =.049). Conclusion: Insufficiency/deficiency of serum 25(OH)D in individuals with T2DM increases the chances of developing the HTW phenotype. [ABSTRACT FROM AUTHOR]