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Evolutionary deletions within the SARS-CoV-2 genome as signature trends for virus fitness and adaptation.
- Source :
-
Journal of Virology . Jan2024, Vol. 98 Issue 1, p1-14. 14p. - Publication Year :
- 2024
-
Abstract
- Coronaviruses are large RNA viruses that can infect and spread among humans and animals. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for coronavirus disease 2019, has evolved since its first detection in December 2019. Deletions are a common occurrence in SARS-CoV-2 evolution, particularly in specific genomic sites, and may be associated with the emergence of highly competent lineages. While deletions typically have a negative impact on viral fitness, some persist and become fixed in viral populations, indicating that they may confer advantageous benefits for the virus's adaptive evolution. This work presents a literature review and data analysis on structural losses in the SARS-CoV-2 genome and the potential relevance of specific signatures for enhanced viral fitness and spread. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SARS-CoV-2
*COVID-19
*BIOLOGICAL evolution
Subjects
Details
- Language :
- English
- ISSN :
- 0022538X
- Volume :
- 98
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Virology
- Publication Type :
- Academic Journal
- Accession number :
- 175216077
- Full Text :
- https://doi.org/10.1128/jvi.01404-23