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Sitagliptin attenuates neuronal apoptosis via inhibiting the endoplasmic reticulum stress after acute spinal cord injury.

Authors :
Tang, Chengxuan
Xu, Tianzhen
Dai, Minghai
Zhong, Xiqiang
Shen, Guangjie
Liu, Liangle
Source :
Human & Experimental Toxicology. Jan-Dec2023, Vol. 42, p1-10. 10p.
Publication Year :
2023

Abstract

Regulation of endoplasmic reticulum stress (ER) stress-induced apoptosis and nerve regeneration is a hopeful way for acute spinal cord injury (SCI). Sitagliptin (Sita) is one of dipeptidyl peptidase-4 (DPP-4) inhibitor, which is beneficial neurons damaged diseases. However, its protective mechanisms of avoiding nerve injury remain unclear. In this study, we further investigated the mechanism of the anti-apoptotic and neuroprotective effects of Sita in promoting locomotor recovery from SCI. In vivo results showed that Sita treatment reduced neural apoptosis caused by SCI. Moreover, Sita effectively attenuated the ER tress and associated apoptosis in rats with SCI. A striking feature was the occurrence of nerve fiber regeneration at the lesion site, which eventually led to significant locomotion recovery. In vitro results showed that the PC12 cell injury model induced by Thapsigargin (TG) also showed similar neuroprotective effects. Overall, sitagliptin showed potent neuroprotective effects by targeting the ER stress-induced apoptosis both in vivo and vitro, thus facilitating the regeneration of the injured spinal cord. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09603271
Volume :
42
Database :
Academic Search Index
Journal :
Human & Experimental Toxicology
Publication Type :
Academic Journal
Accession number :
175197552
Full Text :
https://doi.org/10.1177/09603271231168761