Response to Comment on Chen et al. Ultra-Processed Food Consumption and Risk of Type 2 Diabetes: Three Large Prospective U.S. Cohort Studies. Diabetes Care 2023;46:1335–1344.

The article focuses on addressing concerns raised regarding methodological artifacts in the analysis of the relationship between ultra-processed food (UPF) consumption and the risk of type 2 diabetes (T2D). Topics include the examination of multicollinearity between UPF variables, the risk of false-positive findings due to multiple testing, and the potential confounding introduced by the use of servings/day instead of proportional contribution of non-UPF to total energy intake.