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Mechanochemical synthesis of cerium chlorapatite from a mixture of cerium chloride heptahydrate, dicalcium phosphate dihydrate, and calcium hydroxide for biomedical application.
- Source :
-
Bio-Medical Materials & Engineering . 2024, Vol. 35 Issue 1, p77-85. 9p. - Publication Year :
- 2024
-
Abstract
- BACKGROUND: Cerium ions promote osteoclastogenesis and activate bone metabolism, while cerium oxide nanoparticles exhibit potent anti-inflammatory properties, making them promising for biomedical applications. OBJECTIVE: The purpose of this study was to develop and evaluate a synthesis method for sustained-release cerium-ion bioceramics containing apatite. Substituted apatite was found to be an effective biomaterial. METHODS: Cerium-containing chlorapatite was synthesized using a mechanochemical method employing dicalcium phosphate, cerium chloride heptahydrate, and calcium hydroxide as raw materials. The synthesized samples were characterized using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and Raman spectroscopy. RESULTS: Cerium chlorapatite was successfully synthesized in the 10.1% and 20.1% samples. However, at Ce concentrations higher than 30.2%, the samples consisted of three or more phases, indicating the instability of a single phase. CONCLUSION: The method used in this study was found to be more efficient and cost-effective than the precipitation method for producing substituted apatite and calcium phosphate-based biomaterials. This research contributes to the development of sustained-release cerium-ion bioceramics with potential applications in the field of biomedicine. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09592989
- Volume :
- 35
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Bio-Medical Materials & Engineering
- Publication Type :
- Academic Journal
- Accession number :
- 175159628
- Full Text :
- https://doi.org/10.3233/BME-230073