Back to Search
Start Over
Effects of ezetimibe coadministered with simvastatin on C-reactive protein in a large cohort of hypercholesterolemic patients
- Source :
-
Atherosclerosis (00219150) . Apr2005, Vol. 179 Issue 2, p361-367. 7p. - Publication Year :
- 2005
-
Abstract
- Abstract: Objective:: This study assessed the effect of coadministration of ezetimibe and simvastatin on high sensitivity C-reactive protein (hs-CRP) in a large subject cohort (N =1089). Methods:: Data were combined from two nearly identical prospective trials. After dietary stabilization, washout period, and placebo lead-in period, patients with baseline low-density lipoprotein cholesterol (LDL-C)≥3.75–6.50mmol/l and triglycerides (TG)≤4.0mmol/l were randomized to one of the following daily treatments for 12 weeks: ezetimibe 10mg; simvastatin monotherapy (10, 20, 40, or 80mg); ezetimibe 10mg plus simvastatin (10, 20, 40, or 80mg); or placebo. The primary analysis was the percent change in hs-CRP for the pooled ezetimibe plus simvastatin versus simvastatin monotherapy cohorts. Results:: Ezetimibe coadministered with simvastatin more than doubled the hs-CRP reduction compared to simvastatin monotherapy (−33.3% versus −14.3%, p <0.01). At each individual simvastatin dose level, coadministration therapy exerted significant further incremental hs-CRP reductions compared to simvastatin monotherapy. Similar hs-CRP reductions with coadministered ezetimibe and simvastatin were observed in the major subgroups examined (coronary heart disease, gender, age, baseline LDL-C, and body mass index). Conclusion:: In this large subject cohort, ezetimibe coadministered with simvastatin significantly reduced hs-CRP, suggesting a possible additional anti-inflammatory/anti-atherosclerotic action of combination therapy compared to simvastatin monotherapy. [Copyright &y& Elsevier]
- Subjects :
- *HYPERCHOLESTEREMIA
*C-reactive protein
*ACUTE phase proteins
*CORONARY disease
Subjects
Details
- Language :
- English
- ISSN :
- 00219150
- Volume :
- 179
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Atherosclerosis (00219150)
- Publication Type :
- Academic Journal
- Accession number :
- 17515822
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2004.10.021