A clinical screening algorithm for primary hyperoxaluria type 1 in adults on dialysis.

This article discusses the development and validation of a clinical screening algorithm for the diagnosis of primary hyperoxaluria type 1 (PH1) in adult patients undergoing dialysis. PH1 is a rare genetic disorder characterized by excessive production of oxalate, leading to kidney stones and nephrocalcinosis. The algorithm uses five clinical features, including active nephrolithiasis, presence of nephrocalcinosis, previous graft loss, early initiation of dialysis, and family history of chronic kidney disease, to estimate the probability of PH1. The algorithm showed good performance in terms of discrimination and calibration, and it could be easily implemented in dialysis facilities to identify high-risk patients for further investigation. [Extracted from the article]