Multiple recurrent cutaneous squamous cell carcinomas in situ secondary to epidermodysplasia verruciformis: A case report and successful treatment with aminolevulinic acid photodynamic therapy.

This article discusses a case report of a patient with epidermodysplasia verruciformis (EV), a rare genetic disorder that leads to the development of cutaneous squamous cell carcinoma (cSCC) in situ. The traditional treatment for EV and cSCC in situ is surgical excision, but this can result in disfigured or dysfunctional outcomes. The article presents a successful alternative treatment using 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT), which showed satisfactory results in flattening and shrinking the cSCC in situ lesions. ALA-PDT is a noninvasive treatment that selectively targets abnormal skin tissues without damaging healthy tissues. The article suggests that ALA-PDT may be a promising therapy for multiple cSCC in situ and can potentially prevent cancer development and progression. [Extracted from the article]