Conductive aluminum phthalocyanine-based porous organic polymer as an efficient electrocatalyst for nifedipine detection.

Metal phthalocyanine-based porous organic polymers have gained increasing attention in numerous areas, but their application potential has yet to be comprehensively explored. In this study, a planar polymer (AlPc-CC POP) with excellent electrochemical capabilities was prepared using a straightforward substitution method. The electrocatalytic activity of AlPc-CC POP towards nifedipine (NIF) was investigated using electrochemical analysis. Under optimal conditions, the electrochemical sensor response to NIF was linearly positively correlated at concentrations ranging from 0.04 to 50 μM with a detection threshold of 0.0273 μM. Moreover, the sensor performed well in terms of reproducibility, stability, and selectivity. Notably, the constructed sensing platform enabled the determination of NIF levels in pharmaceuticals and human sera. This work provides a generalized platform for the detection of antihypertensive NIF and validates the potential of phthalocyanine-based porous organic polymer for sensing. [Display omitted] • Synthesis of cellular aluminum phthalocyanine-based porous organic polymer (AlPc-CC POP). • AlPc-CC POP/GCE sensor successfully used for the first time in electrochemistry. • The proposed device performed well in terms of reproducibility, stability, and selectivity. • The sensor was successfully applied to monitor nifedipine in pharmaceutical and biological samples with good accuracy and precision. [ABSTRACT FROM AUTHOR]