2D MOF based-heterostructure with hierarchical architecture as antibacterial wound dressing.

[Display omitted] • Cu-TCPP nanosheets and TiO 2 nanoclusters form a unique Z-scheme heterostructure. • The heterostructure shows excellent photocatalytic activity for ROS generation. • This novel material shows excellent antibacterial performance in vitro / in vivo. • The sufficient ROS and Cu ion ensure the long-term antibacterial activity. Bacterial infections pose a huge threat to human health due to the inevitable emergency of drug resistance. Metal-organic frameworks (MOFs) consisting of metal ions and organic linkers, as emerging efficient antibacterial material, have the merits of structural flexibility and adjustable physicochemical property. With assistance of photosensitive agents as organic linkers, MOFs have great potential in antibacterial application through photocatalytic therapy by the generation of reactive oxygen species (ROS). However, the limited light use efficiency and short lifespan of ROS are two obstacles for their applications. Inspired by the semiconductor heterostructure in photocatalysis, we rationally design and precisely synthesize MOFs based heterostructures, in which the TiO 2 nanoclusters are filled into the pores of Cu-TCPP nanosheets (i.e. TiO 2 NCs@Cu-TCPP HSs). And the composite materials possess three-dimensional (3D) hierarchical architectures, which have advantages of large surface area, excellent light-absorbing ability and photocatalytic efficiency. Significantly, this novel material displays >99.99 % antibacterial efficiency against E. coli and S. aureus within 30 min and preserves the excellent antibacterial ability during reusing three times, which is superior to recently reported photocatalystic-based antibacterial materials. Our study provides new insights into the energy band engineering for enhanced antibacterial performance, paving a way for designing advanced clinical wound dressings. [ABSTRACT FROM AUTHOR]