Back to Search
Start Over
New efficient synthesis of polysubstituted benzo[d]pyrido[1′,2':1,2]imidazo[4,5-f][1,3]diazepines and pyrido[2′,1':2,3]imidazo[1,5-c]quinazolin-7-ium salts via Groebke-Blackburn-Bienaymé/Staudinger/aza-Wittig/carbodiimide-mediated annulation sequence
- Source :
-
Tetrahedron . Feb2024, Vol. 152, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- A new efficient synthesis of polysubstituted benzo[d]pyrido[1′,2':1,2]imidazo[4,5-f][1,3]diazepines and pyrido[2′,1':2,3]imidazo[1,5-c]quinazolin-7-ium salts via sequential Groebke-Blackburn-Bienaymé/Staudinger/aza-Wittig/carbodiimide-mediated annulation has been developed. The three-component Groebke-Blackburn-Bienaymé reactions of 2-azidobenzaldehydes 1 , isocyanides 2 , and 2-aminopyridines 3 produced the azide intermediates 4 , which were treated sequentially with triphenylphosphine and isocyanates to give polysubstituted benzo[d]pyrido[1′,2':1,2]imidazo[4,5-f][1,3]diazepines and pyrido[2′,1':2,3]imidazo[1,5-c]quinazolin-7-ium chlorides in good yields. [Display omitted] [ABSTRACT FROM AUTHOR]
- Subjects :
- *DIAZEPINES
*SALTS
*ISOCYANIDES
*ISOCYANATES
*ANNULATION
*IMIDAZOPYRIDINES
Subjects
Details
- Language :
- English
- ISSN :
- 00404020
- Volume :
- 152
- Database :
- Academic Search Index
- Journal :
- Tetrahedron
- Publication Type :
- Academic Journal
- Accession number :
- 175098481
- Full Text :
- https://doi.org/10.1016/j.tet.2024.133834