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High dispersibility ratiometric fluorescence sensor designed by functionalized mesoporous silica nanopraticles for sensing and imaging of hydrogen peroxide.

Authors :
Liu, Yuhong
Tao, Yuanyuan
An, Xiaofan
Jiang, Xiaoping
Li, Dongwei
Xu, Qian
Zhang, Xingshuang
Zhang, Jing
Xu, Lijie
Gao, Meng
Source :
Colloids & Surfaces A: Physicochemical & Engineering Aspects. Feb2024, Vol. 683, pN.PAG-N.PAG. 1p.
Publication Year :
2024

Abstract

Herein, a mesoporous silica nanoparticle (MSN) based ratiometric fluorescence nanosensor (MSN-BA-SiCD) with improved performance was designed for monitoring hydrogen peroxide (H 2 O 2). Specifically, H 2 O 2 response molecule (BA) with AIE feature was synthesized and encapsulated into MSN channel as the fluoresent recognition site. Afterwards, silane-modified carbon dot (SiCD) was covalently connected to the MSN surface which can effectively prevent the leakage of BA and improve the water dispersibility of the nanosensor. The presence of H 2 O 2 could result in a "turn-on" fluorescence of BA as well as concurrent variation in the fluorescence resonance energy transfer (FRET) signal between SiCD and BA. MSN-BA-SiCD displays a specific blue-to-green resolved emission change in response to H 2 O 2 and the detection limit can be as low as 4.78 × 10−6 M. In addition, the nanosensor exhibited enhanced photostability due to the protection of the material framework. Moreover, the nanosensing system was successfully applied to detect H 2 O 2 in beer, orange juice and living cells. The excellent water dispersibility and photostability of the nanosensor, together with high specificity and biocompatibility, constituted an advanced set of characteristics among existing MSNs, which was expected to further promote the development of H 2 O 2 sensors in the environmental and biological fields. [Display omitted] • A ratio fluorescence nanosensor is designed based on carbon dot modified MSN. • Selective and sensitive detection of H 2 O 2 is achieved by FRET based ratio sensing. • Improved water dispersibility and photostability are exhibited for the nanosensor. • The nanosensor is successfully applied in drink samples and cell imaging. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09277757
Volume :
683
Database :
Academic Search Index
Journal :
Colloids & Surfaces A: Physicochemical & Engineering Aspects
Publication Type :
Academic Journal
Accession number :
175026603
Full Text :
https://doi.org/10.1016/j.colsurfa.2023.132971