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Cover Feature: An Organometallic Gold(I) Bis‐N‐Heterocyclic Carbene Complex with Multimodal Activity in Ovarian Cancer Cells (Chem. Eur. J. 67/2020)
- Source :
-
Chemistry - A European Journal . Dec2020, Vol. 26 Issue 67, p15340-15340. 1p. - Publication Year :
- 2020
-
Abstract
- A cationic AuI N‐heterocyclic carbene complex featuring caffeine‐based ligands has shown potent and selective anticancer effects in ovarian cancer cells. This organogold compound is remarkably stable in physiological conditions. Therefore, the observed therapeutic effects are mainly due to non‐covalent interactions of the gold compound with its pharmacological targets. Among the latter, DNA secondary structures—G‐quadruplexes—play a pivotal role in the mechanisms of anticancer action. More information can be found in the Full Paper by S. M. Meier‐Menches, A. Casini, C. Gerner, et al. on page 15528. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 26
- Issue :
- 67
- Database :
- Academic Search Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 174985098
- Full Text :
- https://doi.org/10.1002/chem.202004459