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Cefazolin-Associated INR Elevation: A Case Report.
- Source :
-
Journal of Pharmacy Practice . Feb2024, Vol. 37 Issue 1, p234-238. 5p. - Publication Year :
- 2024
-
Abstract
- Purpose: To describe a case of significantly elevated international normalized ratio (INR) in a patient on apixaban receiving treatment with intravenous cefazolin in the setting of coronavirus disease 2019 (COVID-19) infection and malnutrition. Summary: A 74-year-old male patient on apixaban receiving cefazolin for osteomyelitis in the setting of COVID-19 and poor nutritional intake presented with internal jugular tunneled catheter site bleeding and an INR of greater than 22.5. Laboratory abnormalities and bleeding concerns were successfully managed with vitamin K and changing antimicrobial therapy from cefazolin to daptomycin. Follow-up labs one week later demonstrated a sustained improvement in coagulopathy. Conclusion: INR prolongation believed to be secondary to cefazolin can be effectively managed with administration of vitamin K and conversion of antimicrobial therapy to an alternative agent. [ABSTRACT FROM AUTHOR]
- Subjects :
- *REFERENCE values
*GENERIC drug substitution
*NUTRITIONAL assessment
*INTRAVENOUS therapy
*FOOD consumption
*SURGICAL complications
*ANTICOAGULANTS
*CEFAZOLIN
*TREATMENT effectiveness
*DIET therapy
*RISK assessment
*MALNUTRITION
*OSTEOMYELITIS
*INTERNATIONAL normalized ratio
*DAPTOMYCIN
*ROUTINE diagnostic tests
*HEMORRHAGE
*VITAMIN K
*COVID-19 pandemic
*DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 08971900
- Volume :
- 37
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Pharmacy Practice
- Publication Type :
- Academic Journal
- Accession number :
- 174943721
- Full Text :
- https://doi.org/10.1177/08971900221132680