术前三叶因子 3, 热休克蛋白 40, 中性粒细胞 / 淋巴细胞比值 与上皮性卵巢癌患者肿瘤细胞减灭术后复发的关系.

Objective: To investigate the relationship between preoperative trefoil factor 3 (TFF3）, heat shock protein 40 (HSP40）,neutrophil/lymphocyte ratio (NLR) and recurrence after tumor cell reduction surgery (CRS) in patients with epithelial ovarian cancer (EOC）. Methods: 140 EOC patients who received CRS treatment in Department of Gynecology of Nanjing Second Hospital from January2016 to May 2017 were selected, and they were divided into recurrent group and non recurrent group based on whether they recurred after CRS. Serum TFF3, HSP40, and NLR were detected and calculated. Single factor and multivariate logistic regression were used to analyze the influencing factors of recurrence after CRS in EOC patients, and the predictive value of recurrence after CRS in EOC patients were analyzed by Subjects’ Job Characteristics (ROC) Curve. Results: Following up for 5 years, 2 cases were lost and 138 EOC patients had a recurrence rate of 52.90% (73/138) after CRS. Compared with the non recurrence group, the recurrence group had a higher proportion of International Federation of Obstetrics and Gynecology (FIGO) stage IV, chemotherapy courses ≥6, and postoperative residual lesions with a maximum residual tumor diameter of ≤1 cm (R1）. The preoperative serum carbohydrate antigen (CA) 125, TFF3,HSP40, and NLR were increased (P＜0.05）. Multivariate logistic regression analysis showed that tumor diameter ≥3 cm, low differentiation, FIGO stage IV, residual lesions of R1 and TFF3 after surgery, HSP40, and increased NLR were independent risk factors for recurrence after CRS in EOC patients (P＜0.05）. ROC curve analysis showed that the area under the curve (AUC) of preoperative serum TFF3, HSP40, and NLR alone and in combination predicted recurrence after CRS in EOC patients were 0.766, 0.763, 0.765, and0.911, respectively. The AUC of preoperative serum TFF3, HSP40, and NLR combined predicted recurrence after CRS in EOC patients was the highest. Conclusion: Elevated levels of preoperative serum TFF3, HSP40, and NLR are independently associated with postoperative recurrence in EOC patients with CRS, and may serve as auxiliary predictive indicators for postoperative recurrence in EOC patients. The combined use of these three indicators has higher predictive value. [ABSTRACT FROM AUTHOR]