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Mechanism of Antitumor Activity of Gold Glyconanoparticles Against Human Colon Adenocarcinoma Cells.

Mechanism of Antitumor Activity of Gold Glyconanoparticles Against Human Colon Adenocarcinoma Cells.

Authors :
Chernykh, I. V.
Kopanitsa, M. A.
Shchulkin, A. V.
Ershov, A. Yu.
Martynenkov, A. A.
Lagoda, I. V.
Kukov, D. V.
Yakusheva, E. N.
Source :
Pharmaceutical Chemistry Journal. Dec2023, Vol. 57 Issue 9, p1362-1366. 5p.
Publication Year :
2023

Abstract

A possible mechanism of the antitumor activity of gold nanoparticles (GNPs) with a surface modified by carbohydrate residues tropic for tumor cell membrane lectins was studied using human colon adenocarcinoma (Caco-2) cells. Caco-2 cells were incubated for 2 and 8 h with GNP solutions. GNPs reduced the level of SH groups during a 2-hour incubation with the cells by an average of 20 times (p < 0.05); during an 8-hour incubation, by an average of 10 times (p < 0.05). The transmembrane potential of mitochondria was observed to decrease on average up to 58% (p < 0.05) after incubation for 8 h with GNP with a surface modified by fucose and lactose. GNPs modified with fucose residues increased the malondialdehyde (MDA) level by 1.5 times (p < 0.05) and the amount of proapoptotic transcription factor p53, by >2.5 times (p < 0.05) after incubation for 8 h. Thus, GNPs with surfaces modified by fucose, lactose, and galactose residues had a cytotoxic effect on Caco-2 cells, activating lipid peroxidation (Au-Fuc) and possibly initiating one of the apoptosis pathways through stimulation of the transcription factor p53 and decreasing the transmembrane potential of mitochondria. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0091150X
Volume :
57
Issue :
9
Database :
Academic Search Index
Journal :
Pharmaceutical Chemistry Journal
Publication Type :
Academic Journal
Accession number :
174878890
Full Text :
https://doi.org/10.1007/s11094-023-02998-8