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Effect of Dimethylsulfoxide on the Nociceptive Response Induced by TRPV1 Ion-Channel Stimulation in Mice.

Authors :
Ivanova, E. A.
Mamonova, S. K.
Voronina, T. A.
Source :
Pharmaceutical Chemistry Journal. Nov2023, Vol. 57 Issue 8, p1159-1163. 5p.
Publication Year :
2023

Abstract

The effect of preventive administration of a single intraperitoneal dose of dimethylsulfoxide (DMSO) at various concentrations (10, 30 and 50%; 10 mL/kg) on the nociceptive response in mice induced by local and systemic activation of TRPV1 ion channels by the TRPV1 agonist capsaicin was studied. DMSO (50%) significantly reduced (by 73.1%) the latency of the response to injection of capsaicin solution into the metatarsus. DMSO in the tail-flick test did not significantly affect the thermal pain threshold, which was elevated after a single subcutaneous injection (above the shoulder blades) of capsaicin at a dose of 1 mg/kg. However, DMSO (30 and 50%) per se raised the pain threshold of mice in the tail-flick test. Because externally applied DMSO enhanced the effect of capsaicin in the capsaicin test, the demonstrated analgesic effect of a single intraperitoneal injection of DMSO in the capsaicin test and tail-flick test in mice was due to its central action rather than to its effect on afferent innervation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0091150X
Volume :
57
Issue :
8
Database :
Academic Search Index
Journal :
Pharmaceutical Chemistry Journal
Publication Type :
Academic Journal
Accession number :
174878865
Full Text :
https://doi.org/10.1007/s11094-024-03021-4