Back to Search
Start Over
Antifungal efficacy of scorpion derived peptide K1K8 against Candida albicans in vitro and in vivo.
- Source :
-
Toxicon . Feb2024, Vol. 238, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- As an alternative class of antimicrobial agents, antimicrobial peptides (AMPs) have gained significant attention. In this study, K1K8, a scorpion AMP derivative, showed effective activity against Candida albicans including clinically resistant strains. K1K8 killed C. albicans cells mainly by damaging the cell membrane and inducing necrosis via an ROS-related pathway. K1K8 could also interact with DNA after damaging the nuclear envelope. Moreover, K1K8 inhibited hyphal development and biofilm formation of C. albicans in a dose-dependent manner. In the mouse skin infection model, K1K8 significantly decreased the counts of C. albicans cells in the infection area. Overall, K1K8 is a potential anti-infective agent against skin infections caused by C. albicans. [Display omitted] • K1K8 showed effective activity against Candida albicans in vitro. • K1K8 damaged the cell membrane, induced necrosis, and interacted with DNA. • K1K8 inhibited hyphal development and biofilm formation of C. albicans. • K1K8 effectively inhibited C. albicans in a mouse skin infection model. • K1K8 is a potential anti-infective agent against skin infections caused by C. albicans. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00410101
- Volume :
- 238
- Database :
- Academic Search Index
- Journal :
- Toxicon
- Publication Type :
- Academic Journal
- Accession number :
- 174872931
- Full Text :
- https://doi.org/10.1016/j.toxicon.2023.107593