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Genetic polymorphism of 38 Y-chromosome short tandem repeats in Beijing han population from China.

Authors :
Liu, Yan
Jiang, Chengtao
Zhao, Dong
Zhang, Jinpei
Wu, Libin
Lu, Di
Yuan, Li
Source :
Journal of Forensic Science & Medicine. Oct-Dec2023, Vol. 9 Issue 4, p340-346. 7p.
Publication Year :
2023

Abstract

Objective: To investigate 38 Y-chromosome short tandem repeat (Y-STR) genetic polymorphisms in Beijing Han and analyze the genetic distance with neighboring or linguistically similar populations. Materials and Methods: In the study, we selected 531 unrelated male individuals of Beijing Han, and the results were statistically analyzed by testing with GSTARâ„¢ 41Y reagents. Results: The allele peak heights were balanced among the Y loci, the amplified fragment ranged from 100 to 500 bps. A total of 531 haplotypes were detected in 531 samples. Eight null genotypes were observed on locus DYS448. One and three double alleles were observed on single-copy locus DYS576 and DYS19, respectively. DYS385 a/b, DYF387S1 a/b, and DYS527 a/b were more common in double copies, but 3, 13, and 11 triple alleles were detected, respectively. The gene diversity values of Y-STRs except DYS391, DYS438, and DYS645 were >0.5. Twenty-seven Y-STRs of Beijing Han population were selected for genetic distance comparison with 17 populations including Changchun Han, with Rst values ranging from 0.0002 to 0.1703. Conclusion: The 38 Y-STRs in this study have strong male lineage identification ability and have great potential for individual identification, kinship identification, Y-STR database construction, and genetic relationship research. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
23495014
Volume :
9
Issue :
4
Database :
Academic Search Index
Journal :
Journal of Forensic Science & Medicine
Publication Type :
Academic Journal
Accession number :
174869304
Full Text :
https://doi.org/10.4103/jfsm.jfsm_105_23