Back to Search
Start Over
Nickel‐Catalyzed Stereoselective Migratory Carboboration of 1,4‐Cyclohexadiene†.
- Source :
-
Chinese Journal of Chemistry . Feb2024, Vol. 42 Issue 4, p356-362. 7p. - Publication Year :
- 2024
-
Abstract
- Comprehensive Summary: Multi‐substituted cyclohexanes play a crucial role as scaffolds in bioactive compounds. While significant progress has been made in synthesizing substituted cyclohexanes, methods for the stereoselective assembly of 1,3‐disubstituted cyclohexanes remain scarce. This study presents a novel approach involving nickel catalysis to achieve stereoselective carboboration of 1,4‐cyclohexadiene. This innovative process allows for the simultaneous introduction of a boron group and an aryl or an alkyl fragment into the 1,4‐cyclohexadiene framework under mild conditions, with exclusive regioselectivity and excellent cis configuration. The resulting products feature a double carbon bond and the incorporation of the boron group, offering significant potential for subsequent transformations and downstream applications. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ARYL group
*DOUBLE bonds
*ALKYL group
*BIOACTIVE compounds
*NICKEL
Subjects
Details
- Language :
- English
- ISSN :
- 1001604X
- Volume :
- 42
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Chinese Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 174782363
- Full Text :
- https://doi.org/10.1002/cjoc.202300503