Comparing the outcomes of laparoscopic proximal and laparoscopic total gastrectomy: A retrospective analysis of a single center in Japan.

Introduction: Despite the increasing performance of laparoscopic proximal gastrectomy (LPG) for proximal gastric cancer and esophagogastric junction cancer, the benefit of LPG over laparoscopic total gastrectomy (LTG) remains to be established. Therefore, this study was conducted to compare postoperative outcomes between LPG and LTG. Methods: Data from 141 patients who underwent LPG or LTG for gastric neoplasm with curative intent between 2016 and 2022 were retrospectively reviewed. Clinicopathological findings, body weight changes, and serological nutritional markers during the postoperative course were evaluated. Results: LPG and LTG were performed in 78 patients and 63 patients, respectively. Patients' characteristics did not differ; however, tumor stages in patients who underwent LTG were more advanced than those who underwent LPG. The mean (± standard deviation) weight loss rate after 1 year was −13.5 (±6.9)% and −18.7 (±6.6)% for LPG and LTG, respectively (p <.01). LTG (OR: 3.326, p <.01), pT disease (OR: 3.000, p =.01), pN disease (OR: 2.708, p =.02), and postoperative chemotherapy (OR: 2.488, p =.05) were correlated with severe weight loss (16% or more) 1 year after surgery, then multivariate analysis identified LTG as an independent factor (p =.01). The mean (± standard deviation) serum total protein level of LPG was significantly higher than that of LTG at 3 months (6.8 ± 0.5 vs. 6.6 ± 0.4 g/dL, p =.02) and 1 year (6.9 ± 0.4 vs. 6.7 ± 0.5 g/dL, p =.01) postoperatively. No difference was observed in postoperative serum hemoglobin and albumin levels. Conclusion: LPG more improved postoperative weight loss than LTG. [ABSTRACT FROM AUTHOR]