Progress in multicellular signal network and drug carriers based on exosomes in regulation of cerebral ischemia-reperfusion injury.

Cerebral stroke has one of the highest incidence, mortality and disability rates worldwide. Although studies have confirmed that reperfusion therapy is an effective strategy for treating stroke patients, the secondary injury of brain tissue caused by reperfusion therapy, which is called cerebral ischaemia reperfusion injury (CIRI), is another medical challenge globally. The microenvironment network constructed by multicellular exosomes plays a regulatory role in the occurrence and development of CIRI. In addition, exosomes have potential value as drug delivery carriers for cerebrovascular diseases due to their stability, the ability to pass through the blood--brain barrier and other characteristics. This study reviews the research progress on the signal network constructed by multiple cells through exosomes and exo-somes as drug carriers in CIRI to provide a reference for research to improve CIRI. [ABSTRACT FROM AUTHOR]