Anticoagulant Activity of Hybrid Molecules Based on 2,2,4-Trimethyl-4-aryl-1,2,3,4-tetrahydroquinoline and Nitrogen-Containing Heterocycles.

The hybrid molecules were obtained by N-alkylation of piperidines, piperazines, tetrahydroisoquinoline, morpholine and phthalimide using N-chloroacetamide derivatives of 2,2,4-trimethyl-4-aryl-1,2,3,4-tetrahydroquinoline. The prepared compounds show moderate inhibitory activity in relation to the blood coagulation factor Xa. [ABSTRACT FROM AUTHOR]