Modèles murins en hémostase.

Since the advent of transgenesis techniques, the mouse model has become the model par excellence in research laboratories, making it possible to model various pathologies or better understand the functions of numerous proteins, in a controlled genetic environment. The resulting challenge has been to develop methods for assessing various phenotypes in a small model such as the mouse. Hemostasis is no exception, and procedures adapted to the measurement of bleeding have emerged. Some of these procedures, and in particular the most frequently used, will be detailed in this review. These experimental models have proliferated in response to the phenotypic heterogeneity of transgenic mice developed in the field of coagulation. We have endeavored to present an example of this heterogeneity, focusing on the mouse models of Willebrand disease that exist today. Indeed, a large number of Willebrand disease models are currently available, attempting as best they can to reproduce the most varied aspects of this extremely polymorphic pathology. These models will be discussed, taking stock of their respective contributions either to improving our knowledge of pathophysiological mechanisms, or as pre-clinical models for the evaluation of new therapies. [ABSTRACT FROM AUTHOR]