ＩＲＥＳ 介导的非帽依赖翻译调控研究进展.

Internal ribosome entry site (IRES) is a special functional element in RNA, which can directly recruit ribosome to initiate protein translation independently of the 5' end cap structure. It has been found to be closely related to a variety of cell processes. Recently, IRES have attracted a lol of attention due to increasing evidence that they play an extremely important role in the regulation of circular RNA translation. This paper reviews the current mechanism of IRES-mediated translation regulation in eukaryotic cells, and summarizes the bioinformatics tools related to IRES elements. [ABSTRACT FROM AUTHOR]