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The glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 catalyzes the activation of testosterone.
- Source :
-
Journal of Steroid Biochemistry & Molecular Biology . Feb2024, Vol. 236, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- Testosterone biosynthesis from its precursor androstenedione is thought to be exclusively catalysed by the 17β-hydroxysteroid dehydrogenases—HSD17B3 in testes, and AKR1C3 in the ovary, adrenal and peripheral tissues. Here we show for the first time that the glucocorticoid activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1) can also catalyse the 17β-reduction of androstenedione to testosterone, using a combination of in vitro enzyme kinetic assays, mathematical modelling, and molecular docking analysis. Furthermore, we show that co-expression of HSD11B1 and AKR1C3 increases testosterone production several-fold compared to the rate observed with AKR1C3 only, and that HSD11B1 is likely to contribute significantly to testosterone production in peripheral tissues. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TESTOSTERONE
*ENZYMES
*MOLECULAR docking
*BIOSYNTHESIS
*ANDROSTENEDIONE
*GONADS
Subjects
Details
- Language :
- English
- ISSN :
- 09600760
- Volume :
- 236
- Database :
- Academic Search Index
- Journal :
- Journal of Steroid Biochemistry & Molecular Biology
- Publication Type :
- Academic Journal
- Accession number :
- 174667293
- Full Text :
- https://doi.org/10.1016/j.jsbmb.2023.106436