تأثیر عصاره آبی ریشه گیاه ثعلب بر غلظت سرمی هورمون کوله سیستوکینین و وزن بدن در موشهای صحرایی نر.

Introduction: The growing prevalence of obesity is one of the biggest health challenges across the world. Stimulating the body metabolism and increasing its energy use through herbal agents is one of the main methods used to treat obesity. Materials and Methods: This study was conducted on 50 adult male Wistar rats weighing between 180 and 200 g randomly divided into 5 groups of equal sizes, including a negative control group (receiving no drugs), a sham control group (receiving 1 ml of distilled water) and experimental groups 1, 2 and 3 (receiving 20, 40 and 80 mg/kg aqueous extract of Orchid roots, in respective order). The extract was injected intraperitoneally to the experimental groups for 28 days. On the 29th day, the rats' blood samples were taken to examine their serum concentration of cholecystokinin. The rats' body weight was measured on a daily basis throughout the experiment. Statistical analysis were performed in SPSS using the one way ANOVA and Duncan's post-hoc test. Results: Orchid root aqueous extract injection in a dose-dependent led to significant increase in serum levels of cholecystokinin hormone and decrease in food intake and body weight than the control group (p<0.05). Conclusion: Through increased serum levels of cholecystokinin hormone, aqueous extract of orchid plant root reduces body weight. [ABSTRACT FROM AUTHOR]