تأثیر مصرف عصاره آبی الکلی گیاه گلپر در دوران بارداری بر میزان آنزیم های کبدی آلبومین و پروتئین تام در نوزادان موشهای صحرایی نر.

Introduction: Liver is one of the vital organs in the body with a key role in regulating many physiological mechanisms. The present study was conducted to examine the effect of the hydroalcoholic extract of Heraclum persicum administered to the mother rats during pregnancy on liver enzymes and blood biochemical factors in their infant male rats. Materials and Methods: The present experimental study was conducted on 40 infant male Wistar rats divided into 5 groups of 8, whose mothers were then divided into 5 groups of 8 during their pregnancy, including a negative control group, a sham control group and three experimental groups. The negative control group did not receive any treatments while the sham control group received only distilled water. Experimental groups 1, 2 and 3 received, respectively, 100, 200 or 400 mg/kg oral doses of Heracleum persicum on a daily basis for a period of 21 days (the pregnancy term). At the end of the pregnancy and when the male infant rats were 25 days old, the infant rats' blood samples were taken and their liver enzymes (alanine transaminase [ALT], aspartate aminotransferase [AST] and alkaline phosphatase [ALP]) and biochemical factors (Albumin and total serum protein) were measured. The data obtained were analyzed using the ANOVA and Tukey's post-hoc test. P<0.05 was taken as the level of statistical significance. Results: The AST and ALT levels had increased significantly in experimental groups 2 and 3 compared to in the negative and sham control groups (P<0.05). The Albumin level had also increased significantly in experimental group 3 compared to in the negative and sham control groups (P<0.05). There was also a significant difference between ALP and serum protein levels in the experimental groups and the negative and sham control groups. Conclusion: The hydroalcoholic extract of Heracleum persicum may have changed the liver function and increased ALT and AST as a result of its furanocoumarin and trans-anethole content. The extract's alkaloid and flavonoid content also increase serum Albumin levels. [ABSTRACT FROM AUTHOR]