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Significance of the Pretreatment Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Predicting the Response to Neoadjuvant Chemotherapy and Survival Rates in Extremity Osteosarcoma: A Multicentre Prospective Study.
- Source :
-
Cancer Investigation . December 2023, Vol. 41 Issue 10, p816-820. 5p. - Publication Year :
- 2023
-
Abstract
- We aimed to assess the effects of pretreatment neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios on the response to neoadjuvant chemotherapy and survival rates in patients with extremity osteosarcoma. Patients with high-grade osteosarcoma admitted to oncologic centers affiliated with Iran University of Medical Sciences, Tehran, Iran from 2015 to 2021 were evaluated retrospectively to assess the impact of complete blood count-related parameters on the pathologic response after neoadjuvant chemotherapy. Then, patients were followed up prospectively to evaluate the survival rates. All patients received at least three cycles of cisplatin/doxorubicin regimen, preoperatively. In this study, the cut-off values for high neutrophil-to-lymphocyte and high platelet-to-lymphocyte ratio were considered 3.28 and 128, respectively. One hundred eighty-six patients were enrolled. Patients with high neutrophil-to-lymphocyte ratio and high platelet-to-lymphocyte ratio had a significantly lower overall survival rates (20.7 [95% CI 18–23.5] month vs. 34.6 [95% CI 33.2–36], p = 0.003 and 21.9 [95% CI 20.2–23.6] month versus 35.3 [95% CI 33.9–36.7], p = 0.002; respectively). Moreover, disease-free survival of patients with high platelet-to-lymphocyte ratio was worse than patients with low platelet-to-lymphocyte ratio (20.4 [95% CI 18.4–22.4] month vs. 32.7 [95% CI 30.8–34.7], p = 0.02). Our study showed that neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios at the baseline can predict the survival of patients with high-grade osteosarcoma. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THERAPEUTIC use of antineoplastic agents
*ADJUVANT chemotherapy
*PLATELET lymphocyte ratio
*ACADEMIC medical centers
*CONFIDENCE intervals
*OSTEOSARCOMA
*DOXORUBICIN
*RETROSPECTIVE studies
*NEUTROPHIL lymphocyte ratio
*SURVIVAL rate
*TREATMENT effectiveness
*HOSPITAL wards
*CISPLATIN
*RESEARCH funding
*COMBINED modality therapy
*BLOOD cell count
*PROGRESSION-free survival
*PREDICTION models
*LONGITUDINAL method
*ONCOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 07357907
- Volume :
- 41
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Cancer Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 174558664
- Full Text :
- https://doi.org/10.1080/07357907.2023.2283456