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Facile synthesis of 3-(pyrazol-1-yl) succinimides from Ag2CO3-catalyzed aza-Michael addition of pyrazoles to maleimides.
- Source :
-
Synthetic Communications . 2023, Vol. 53 Issue 24, p2088-2096. 9p. - Publication Year :
- 2023
-
Abstract
- Herein, an effective and facile synthesis of 3-(pyrazol-1-yl) succinimides is first presented through silver-catalyzed aza-Michael addition of pyrazoles to maleimides. In the presence of 5 mol% of Ag2CO3, various pyrazoles smoothly reacted with maleimides in dichloroethane at 100 °C, to generate 3-(pyrazol-1-yl) succinimides in excellent yields. Notably, 3-substituted asymmetric pyrazoles exclusively give 3-pyrazolyl succinimides in excellent yields possibly due to the steric bulk of the 3-substituent excluding the formation of addition products of N². The method can also extend to gram scale. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SUCCINIMIDES
*PYRAZOLES
*MALEIMIDES
*ETHYLENE dichloride
*AZA compounds
*CARBONATES
Subjects
Details
- Language :
- English
- ISSN :
- 00397911
- Volume :
- 53
- Issue :
- 24
- Database :
- Academic Search Index
- Journal :
- Synthetic Communications
- Publication Type :
- Academic Journal
- Accession number :
- 174538848
- Full Text :
- https://doi.org/10.1080/00397911.2023.2270636