Functional expression of TRPV1 in human peripheral blood basophils and its regulation in atopic dermatitis.

This article discusses the expression and regulation of the transient receptor potential vanilloid 1 (TRPV1) channel in human basophils and its potential role in atopic dermatitis (AD). The study found that basophils express TRPV1 at the mRNA and protein levels, and its expression is higher in basophils compared to other immune cells. Activation of TRPV1 in basophils resulted in changes in calcium levels, IL-6 release, and apoptosis. TRPV1 expression was also found to be upregulated in AD, and its surface content was modulated by inflammatory mediators. These findings suggest that TRPV1 may play a pro-inflammatory and pruritic role in basophil function, making it a potential therapeutic target for AD and other basophil-associated inflammatory skin diseases. [Extracted from the article]