不同握力水平对C-反应蛋白与糖尿病前期人群血糖变化的调节作用.

Objective To explore the relationship between C-reactive protein (CRP) and blood glucose in prediabetic population through a cohort study, and to explore whether grip strength can regulate the correlation. Methods Based on the China health and retirement longitudinal study (CHARLS), the middle-aged and elderly people who participated in the baseline survey (2011) and the follow-up survey (2015) were selected. Multiple Logistic regression model was used to analyze the relationship between CRP and pre-diabetic people who developed into diabetes or returned to normal blood glucose as well as the regulatory effect of grip strength. Results A total of 2 811 subjects were included in this study. During the follow-up period, 441 (15.7%) developed diabetes, 1 762 (62.7%) maintained the status of prediabetes, and 608 (21.6%) returned to normal blood glucose. After adjusting the covariates, the results of multiple Logistic regression showed that compared with CRP first quartile (Quartile 1), both CRP third quartile (Quartile 3) and fourth quartile (Quartile 4) increased the risk of diabetes, their OR values and 95%CI being 1.63 (1.18-2.24) and 1.67 (1.14-2.17), respectively, and the probability of returning to normal blood glucose was reduced by 32% in Quartile 4 group. In the low grip strength group, the risk of developing diabetes in the Quartile 3 and Quartile 4 groups was 1.80 (95%CI:1.13-2.87) and 2.04 (95%CI:1.29-3.23) times higher than that in the Quartile1 group, while the Quartile 4 group reduced the chance of returning to normal blood sugar by 41%, but the association was not observed in the high grip strength group. Conclusion CRP is closely related to the change of blood glucose in pre-diabetic population, but high grip strength can regulate this correlation. [ABSTRACT FROM AUTHOR]