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Gene expression and regulation of nerve growth factor in atopic dermatitis mast cells and the human mast cell line-1
- Source :
-
Journal of Neuroimmunology . Apr2005, Vol. 161 Issue 1/2, p87-92. 6p. - Publication Year :
- 2005
-
Abstract
- Abstract: The gene expression and regulation of nerve growth factor (NGF) in atopic dermatitis (AD) and the human mast cell line (HMC)-1 was investigated at the molecular level. NGF-stimulation of HMC-1 cells resulted in increases in tryptase activity and histamine contents, paralleled by an increase of tryptase and histamine at the transcriptional level. Also, an increased expression of NGF was found in AD lesions, in association with increased systemic NGF plasma levels. Further cutaneous sources for increased NGF levels were keratinocytes and fibroblasts. These findings demonstrate an increased expression of NGF in AD and effects on tryptase and histamine. Mast cells may be major mediators of neurotrophin effects in AD. [Copyright &y& Elsevier]
- Subjects :
- *NERVE growth factor
*GENE expression
*CYTOKINES
*ATOPIC dermatitis
Subjects
Details
- Language :
- English
- ISSN :
- 01655728
- Volume :
- 161
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 17435593
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2004.12.019