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Improvements in acne and skin oiliness with tazarotene 0.045% lotion in patients with oily skin.
- Source :
-
Journal of Dermatological Treatment . 2023, Vol. 34 Issue 1, p1-8. 8p. - Publication Year :
- 2023
-
Abstract
- Excessive sebum production is a factor in acne development. Tazarotene 0.045% lotion has demonstrated reductions in acne lesions and acne-induced sequelae. Evaluate efficacy, changes in skin oiliness, and safety with tazarotene 0.045% lotion in participants with moderate-to-severe acne and oily skin. In two phase 3, double-blind, 12-week studies (NCT03168321; NCT03168334), participants aged ≥ 9 years with moderate-to-severe acne were randomized 1:1 to once-daily tazarotene 0.045% lotion or vehicle lotion (N = 1614). This pooled, post hoc analysis included only participants self-categorized with oily skin at baseline on the Acne-Specific Quality of Life questionnaire item 19 (scores: 0 [extremely oily] to 6 [not at all oily]). Inflammatory/noninflammatory lesion counts, treatment success, skin oiliness, treatment-emergent adverse events (TEAEs), and cutaneous safety/tolerability were evaluated. In all participants with oily skin (n = 793), tazarotene provided greater reductions in inflammatory/noninflammatory lesions (p < 0.001, both) and greater treatment success rates versus vehicle (p < 0.01) at week 12. Over two-thirds of polymeric lotion-treated participants had subjective skin oiliness reductions by week 12, with around a third reporting 'low/not' oily skin. Tazarotene TEAE rates were similar to the overall population. Once-daily treatment with tazarotene 0.045% polymeric emulsion lotion may help improve patient-perceived skin oiliness in those with moderate-to-severe acne. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OINTMENTS
*ACNE
*FACTORS of production
*QUALITY of life
*SEBUM
Subjects
Details
- Language :
- English
- ISSN :
- 09546634
- Volume :
- 34
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Dermatological Treatment
- Publication Type :
- Academic Journal
- Accession number :
- 174159926
- Full Text :
- https://doi.org/10.1080/09546634.2022.2147391