小而密低密度脂蛋白胆固醇、CXC型趋化因子配体12 与糖尿病患者并发心血管疾病的相关性.

Objective To investigate the correlation between serum levels of small dense low density lipoprotein-cholesterol （sdLDL-C） and chemokine CXC motifligand12（CXCL12） and diabetes mellitus with car⁃ diovascular disease（CVD). Methods A total of 256 diabetic patients treated in our hospital between June 2021 and September 2022 were selected as the diabetic group. The patients were grouped according to whether they had combined CVD or not. And the serum sdLDL-C as well as CXCL12 levels of each group were compared with healthy volunteers. Risk factors for the complication of CVD in diabetic patients were analyzed. To analyze the diag⁃ nostic value of sdLDL-C, CXCL12 and combined test for diabetic patients with complicated CVD. Results Serum sdLDL-C and CXCL12 levels were higher in the diabetes group than in the control group （P < 0.05). The duration of disease, BMI, LDL-C, and serum sdLDL-C and CXCL12 levels were higher in the cardiovascular disease group than in the non-cardiovascular disease group （P < 0.05). A multifactorial logistic regression analysis showed that sdLDL-C and CXCL12 were independent risk factors for the complication of CVD in diabetic patients （P < 0.05). The sensitivity and specificity of serum sdLDL-C and CXCL12 combined test were higher than that of single test. Conclusion Elevated serum sdLDL-C and CXCL12 levels in patients with diabetes mellitus are independent risk factors for the complication of CVD, and the combination of these two tests has a high diagnostic value for diabetes mellitus with CVD. [ABSTRACT FROM AUTHOR]