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Silk fibroin/chitosan pH-sensitive controlled microneedles.
- Source :
-
Journal of Materials Science . Dec2023, Vol. 58 Issue 46, p17711-17725. 15p. - Publication Year :
- 2023
-
Abstract
- Silk fibroin is a widely used biocompatible medical material with tunable mechanical, degradability and environmental non-toxicity. This paper prepared the silk fibroin/chitosan hydrogel microneedle with pH sensitivity by blending silk fibroin with chitosan to induce graft cross-linking. The cross-linked silk fibroin/chitosan microneedles network is expanded by hydrogen ions and water molecules, forming a more significant swelling. In vitro, the transdermal drug release showed that insulin loaded in microneedles exhibited pH-sensitive drug release behavior and was released faster under acidic conditions than under neutral conditions. By changing the pH of the solution, microneedles can achieve a stimulating response to the environment, thereby intelligently regulating the transdermal release of insulin. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SILK fibroin
*BIOMEDICAL materials
*HYDROGEN ions
*INSULIN
Subjects
Details
- Language :
- English
- ISSN :
- 00222461
- Volume :
- 58
- Issue :
- 46
- Database :
- Academic Search Index
- Journal :
- Journal of Materials Science
- Publication Type :
- Academic Journal
- Accession number :
- 174097498
- Full Text :
- https://doi.org/10.1007/s10853-023-09148-1