Synthesis and Study of New Anticoagulant Candidates Based on 6-Aryl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones.

ction of 6-aryl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones with 3-acetylcoumarins led to the formation of a new series of 1-[2-oxo-2-(2-oxo-2H-chromen-3-yl)ethylidene]-6-aryl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2(1H)-ones. Primary in vitro screening of anticoagulant activity against coagulation factors Xa and XIa was performed for all target compounds. The IC50 value was also determined for the structures that showed the highest inhibition values among synthesized molecules. [ABSTRACT FROM AUTHOR]