Supervivencia de Pasteurella multocida aislada de conejo a la lisis inducida por el sistema complemento.

Pasteurellosis is one of the most serious bacterial diseases of rabbits, causes considerable economic damage in production systems worldwide and is a widely proven zoonosis with cases in humans infected by companion animals. The activated complement system causes lysis of various pathogenic microorganisms by the formation of the membrane attack complex. The objective of the present work was to evaluate the survivability of a virulent isolate of Pasteurella multocida type A to human serum complement activity. A female rabbit was referred as a clinical case of pneumonic pasteurellosis, a nasal swab was performed for isolation and identification. P. multocida was isolated in pure culture, characterized by standard biochemical identification tests, then challenged for 30 min at 37°C with normal serum and heatinactivated serum. Lysis by complement action had a significant reduction in the viability of the microorganism with respect to the culture challenged with inactivated complement (p< 0.05), however, a significant percentage 51.07 ± 1.70 % managed to evade complement lytic activity. In the context of health, it is concluded that the complement system offers partial protection against infections by P. multocida serotype A causing pneumonic pasteurellosis in rabbits. [ABSTRACT FROM AUTHOR]