Dichapetalin-type triterpenoids from Dichapetalum longipetalum and their anti-inflammatory activity.

A phytochemical research on the twigs of Dichapetalum longipetalum (Turcz.) Engl. Resulted in five undescribed dichapetalin-type triterpenoids 1 – 5. Their chemical structures were determined by spectroscopic analysis of HR-ESIMS and NMR spectra and the absolute configuration of compound 1 was completely elucidated by single crystal X-ray crystallography. Through preliminary anti-inflammatory activity assessment, compound 1 exhibited inhibitory effect on LPS-induced NO production in RAW264.7 murine macrophages with an IC 50 value of 2.09 μM. [Display omitted] • A phytochemical research on the twigs of Dichapetalum longipetalum (Turcz.) Engl. Resulted in five undescribed dichapetalin-type triterpenoids. • The absolute stereochemistry of compound 1 were confirmed by the single crystal X-ray diffraction. • Compounds 1 exhibited more potent inhibition against NO release with IC 50 of 2.09 μM than positive control dexamethasone. [ABSTRACT FROM AUTHOR]