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ALPK3 Functions as a Pseudokinase.

Authors :
Feng, Wei
Bogomolovas, Julius
Wang, Li
Li, Mengchen
Chen, Ju
Source :
Circulation. 12/5/2023, Vol. 148 Issue 23, p1911-1913. 3p.
Publication Year :
2023

Abstract

The article discusses the ALPK3 gene and its potential role in cardiomyopathies. While there are conflicting findings regarding ALPK3's kinase activity, recent studies suggest that ALPK3 functions as a pseudokinase rather than a true kinase. The article presents evidence from in vitro and in vivo experiments, including an in vitro phosphorylation assay and the generation of knock-in mice with a mutated ALPK3 gene. These findings suggest that ALPK3 variants associated with cardiomyopathy may affect other aspects of the protein rather than its kinase activity. [Extracted from the article]

Details

Language :
English
ISSN :
00097322
Volume :
148
Issue :
23
Database :
Academic Search Index
Journal :
Circulation
Publication Type :
Academic Journal
Accession number :
174014230
Full Text :
https://doi.org/10.1161/CIRCULATIONAHA.123.065993