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ALPK3 Functions as a Pseudokinase.
- Source :
-
Circulation . 12/5/2023, Vol. 148 Issue 23, p1911-1913. 3p. - Publication Year :
- 2023
-
Abstract
- The article discusses the ALPK3 gene and its potential role in cardiomyopathies. While there are conflicting findings regarding ALPK3's kinase activity, recent studies suggest that ALPK3 functions as a pseudokinase rather than a true kinase. The article presents evidence from in vitro and in vivo experiments, including an in vitro phosphorylation assay and the generation of knock-in mice with a mutated ALPK3 gene. These findings suggest that ALPK3 variants associated with cardiomyopathy may affect other aspects of the protein rather than its kinase activity. [Extracted from the article]
- Subjects :
- *CARDIOMYOPATHIES
*PHOSPHORYLATION
*CRISPRS
*GENES
*MICE
Subjects
Details
- Language :
- English
- ISSN :
- 00097322
- Volume :
- 148
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Circulation
- Publication Type :
- Academic Journal
- Accession number :
- 174014230
- Full Text :
- https://doi.org/10.1161/CIRCULATIONAHA.123.065993