早期开髓减压引流术联合氢氧化钙对牙髓炎患者咀嚼功能 及血清 CD14、HIF-1琢、CX3CL1 水平的影响.

Objective: To investigate the effect of calcium hydroxide combined with early myelotomy decompression and drainage surgery on serum leukocyte differentiation antigen-14 (CD14), hypoxia inducible factor-1α (HIF-1α) and CX3C chemokine ligand 1 (CX3CL1) levels and masticatory function in patients with pulpitis. Methods: 174 patients with pulpitis who were treated in Lianyungang Hospital affiliated to Xuzhou Medical University were selected from January 2020 to April 2022, the patients were divided into control group and study group according to the double chromosphere method, 87 cases each. Both groups underwent early myelotomy decompression and drainage surgery, the control group was filled with zinc oxide eugenol cement, the study group was filled with calcium hydroxide paste filling. The efficacy, visual analog score of pain (VAS), bite force, chewing efficiency, CD14, HIF-1α and CX3CL1 levels in two groups were observed. Results: Compared with the control group, the clinical total effective rate was further increased in the study group (P＜0.05) . Compared with the control group, the VAS score decreased, bite force increased, chewing efficiency increased and serum CD14, HIF-1α and CX3CL1 levels decreased in the study group 7 d after treatment (P＜0.05) . Conclusion: Early pulp opening decompression and drainage of pulpitis was treated with calcium hydroxide filling, can effectively reduce the pain in the patient, improve the chewing function, lift the bite force, regulation of the serum CD14, HIF-1α and CX3CL1 levels, improve the clinical treatment effect. [ABSTRACT FROM AUTHOR]