An efficient organopromotor L‐arginine facilitated synthesis of thiazolo[3,2‐a]pyrimidine derivatives in EtOH:H2O solvent.

An efficient, one pot, multicomponent, L‐arginine catalyzed synthesis of thiazolo[3,2‐a]pyrimidines is described. L‐arginine is an easily available, biodegradable, inexpensive, promising bio‐organic molecule. The current strategy is the first example of amino acid promoted, green synthesis of a series of thiazolo[3,2‐a]pyrimidines via the formation of CN and CC bonds. The major advantages of the present methodology such as recyclability of catalyst, operational simplicity, easy scale‐up, wide substrate scope, easy work‐up, inexpensive, excellent yields, and high atom economy make it a distinct improvement over the prevailing strategies. [ABSTRACT FROM AUTHOR]