Whole process establishment of carrier-free 177Lu production: from small-scale production to pilot-scale production.

In this research, whole process of small-scale and pilot-scale carrier-free 177Lu production have been developed and curie-level 177Lu was achieved. Additionally, the methodology of product key quality control inspection has been developed and verified, the control standard has been established. Key indicators of the product have met or exceeded the requirements of the European Pharmacopoeia. Up to date, about 30 Ci carrier-free 177Lu product has been obtained based on this development. The carrier-free 177Lu obtained in this research has been used in nearly 20 trial parties including units for drug R & D and clinical research. [ABSTRACT FROM AUTHOR]