Circular RNAs as Trojan horses of leukaemia: A promising path to cancer precision medicine.

This article discusses the role of circular RNAs (circRNAs) in driving mixed lineage leukemia (MLL) chromosomal translocations in acute myeloid leukemia (AML). CircRNAs, a subclass of non-coding RNA transcripts, have been found to bind to DNA and impact various cellular processes, including oncogenesis. The discovery of circMLL(9,10) in pediatric leukemia patients has shed light on the molecular basis of MLL mutations and offers potential for transforming clinical practice in leukemia and other cancers. The article explores the implications and future prospects of circRNAs, including their potential use as biomarkers for early diagnosis, prognostic indicators, personalized therapeutic targets, and as vehicles for delivering therapeutic proteins. The integration of circRNAs into clinical practice could revolutionize disease management and improve outcomes for patients. [Extracted from the article]