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Access to Chiral O,O‐Acetals Enabled by Palladium‐Catalyzed Asymmetric Addition of Oximes to Alkoxyallenes.
- Source :
-
Chemistry - A European Journal . 11/21/2023, Vol. 29 Issue 65, p1-7. 7p. - Publication Year :
- 2023
-
Abstract
- Enantiomerically pure acyclic O,O‐acetal compounds (up to 97 % ee) have been accessed through chemo‐, regio‐ and enantioselective palladium‐catalyzed addition of oximes to alkoxyallenes. DFT calculations support that a protonative hydropalladation pathway is favourable, in which the hydrogen bonding interaction between the amide group of the diphosphine ligand and the alkoxyallene is critical for the highly stereoselective formation of the dioxygenated stereogenic center. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ENANTIOMERIC purity
*HYDROGEN bonding interactions
Subjects
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 29
- Issue :
- 65
- Database :
- Academic Search Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 173892806
- Full Text :
- https://doi.org/10.1002/chem.202301883