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Total syntheses of pongaflavone and its natural analogues.
- Source :
-
Journal of Asian Natural Products Research . Nov2023, Vol. 25 Issue 11, p1085-1096. 12p. - Publication Year :
- 2023
-
Abstract
- The efficient total synthesis of anti-tumor natural product pongaflavone (1) was described starting from commercially available 2,4-dihydroxyacetophenone (9) via seven steps and in 16% overall yield. Its two natural analogues pongachromene (2) and 7,8-(2",2"-dimethylpyrano)-5,3',4'-trihydroxy-3-methoxyflavone (3) were also synthesized following the similar procedure with the yields of 11% and 18%, respectively. Their preliminary anti-tumor activities were evaluated by the inhibition effect on A549 cells. The result showed that this kind of natural products exhibited different levels of anti-tumor activity. Among them, pongachromene (2) displayed the best anti-tumor activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *EXPERIMENTAL design
*MEDICINAL plants
*CELL culture
*ANTINEOPLASTIC agents
*LUNG tumors
*NUCLEAR magnetic resonance spectroscopy
*FLAVONES
*MASS spectrometry
*DESCRIPTIVE statistics
*CELL proliferation
*RESEARCH funding
*PLANT extracts
*CELL lines
*CHROMATOGRAPHIC analysis
*MOLECULAR structure
*THIN layer chromatography
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 25
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 173858926
- Full Text :
- https://doi.org/10.1080/10286020.2023.2193697