Nutritional considerations for a new era: A CF foundation position paper.

• Nutrition care should be individualized using clinical data and goals of PwCF. • Consider potential CV complications associated with the legacy, high fat/high calorie CF diet. • FI is a concern in PwCF from all socioeconomic sectors and screening should be part of standard. • There is a lack of data to make specific suggestions about salt intake in those PwCF and hypertension. • Inline enzyme cartridges are effective for digesting nutrients and promoting weight gain in PwCF. To provide interim advice and considerations to the CF Community around CF nutrition in the current era. The Cystic Fibrosis (CF) Foundation organized a multidisciplinary committee to develop a Nutrition Position Paper based on the rapidly changing nutrition landscape in CF, due in part to widespread use of cystic fibrosis transmembrane regulator highly effective modulator therapy (HEMT). Four workgroups were formed: Weight Management, Eating Behavior/Food Insecurity, Salt Homeostasis and Pancreatic Enzyme use. Each workgroup conducted their own focused review of the literature. The committee summarized current understanding of issues pertaining to the four workgroup topics and provided 6 key take-aways around CF Nutrition in the new era. People with CF (pwCF) are living longer, particularly with the advent of HEMT. The traditional high fat, high calorie CF diet may have negative nutritional and cardiovascular consequences as pwCF age. Individuals with CF may have poor diet quality, food insecurity, distorted body image, and an higher incidence of eating disorders. An increase in overweight and obesity may lead to new considerations for nutritional management, given potential effects of overnutrition on pulmonary and cardiometabolic parameters. [ABSTRACT FROM AUTHOR]