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Macular neovascularization in inherited retinal diseases: A review.
- Source :
-
Survey of Ophthalmology . Jan2024, Vol. 69 Issue 1, p1-23. 23p. - Publication Year :
- 2024
-
Abstract
- Inherited retinal diseases (IRDs) are the most common cause of blindness in working-age adults. Macular neovascularization (MNV) may be a presenting feature or occurs as a late-stage complication in several IRDs. We performed an extensive literature review on MNV associated with IRDs. MNV is a well-known complication of Sorsby fundus dystrophy and pseudoxanthoma elasticum. Those with late-onset Stargardt disease may masquerade as exudative age-related macular degeneration (AMD) when MNV is the presenting feature. Peripherinopathies may develop MNV that responds well to a short course of anti-vascular endothelial growth factor (anti-VEGF) therapy, while bestrophinopathies tend to develop MNV in the early stages of the disease without vision loss. Enhanced S-cone syndrome manifests type 3 MNV that typically regresses into a subfoveal fibrotic nodule. MNV is only a rare complication in choroideraemia and rod-cone dystrophies. Most IRD-related MNVs exhibit a favorable visual prognosis requiring less intensive regimens of anti-vascular endothelial growth factor therapy compared to age-related macular degeneration. We discuss the role of key imaging modalities in the diagnosis of MNV across a wide spectrum of IRDs and highlight the gaps in our knowledge with respect to the natural history and prognosis to pave the way for future directions of research. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00396257
- Volume :
- 69
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Survey of Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 173852331
- Full Text :
- https://doi.org/10.1016/j.survophthal.2023.07.007