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A Clinical Decision Tool for Risk Stratifying Patients with Systemic Sclerosis-Related Pulmonary Hypertension.
- Source :
-
Lung . Dec2023, Vol. 201 Issue 6, p565-569. 5p. - Publication Year :
- 2023
-
Abstract
- We devised a scoring system to identify patients with systemic sclerosis (SSc) at risk for pulmonary hypertension (PH) and predict all-cause mortality. Using 7 variables obtained via pulmonary function testing, echocardiography, and computed tomographic chest imaging, we applied the score to a retrospective cohort of 117 patients with SSc. There were 60 (51.3%) who were diagnosed with PH by right heart catheterization. Using a scoring threshold ≥ 0, our decision tool predicted PH with a sensitivity, specificity, and accuracy of 0.87 (95% CI 0.75, 0.94), 0.74 (95% CI 0.60, 0.84), and 0.80 (95% CI 0.72, 0.87), respectively. When adjusted for age at PH diagnosis, sex, and receipt of pulmonary arterial vasodilators, each one-point score increase was associated with an adjusted HR of 1.19 (95% CI 1.05, 1.34) for all-cause mortality. With further validation in external cohorts, our simplified clinical decision tool may better streamline earlier detection of PH in SSc. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03412040
- Volume :
- 201
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Lung
- Publication Type :
- Academic Journal
- Accession number :
- 173821644
- Full Text :
- https://doi.org/10.1007/s00408-023-00646-2