Mutations of the dimerization site of glycoprotein (GP) VI result in abolished expression.

[Display omitted] • Here, we aimed to study the role of Glycoprotein VI (GPVI) dimerization in platelet activation in vivo. • The previously identified putative dimerization site of GPVI was mutated to disrupt the GPVI dimerization on the platelet surface. • Two different mutations of the GPVI dimerization site resulted in a loss of GPVI surface abundance in vivo. • Multivalent ligands (fibrillar collagen) of GPVI can elicit platelet activation also at very low GPVI density levels. [ABSTRACT FROM AUTHOR]